1988 US Open – Men's singles

Mats Wilander defeated three-time defending champion Ivan Lendl in a rematch of the previous year's final, 6–4, 4–6, 6–3, 5–7, 6–4 to win the men's singles tennis title at the 1988 US Open. It was his first US Open singles title and seventh and last major singles title overall. It was the longest US Open men's singles final in history, lasting 4 hours and 54 minutes. With the win, Wilander gained the world No. 1 singles ranking for the first time, displacing Lendl.

Aged 15 years and 2 months, Tommy Ho was the youngest man in the Open Era to appear in the main draw of a major. He lost in the first round to Johan Kriek.

This tournament marked the first major main draw appearances of future 14-time major champion Pete Sampras and future four-time major champion Jim Courier.