1972 US Open – Men's singles

Men's singles
1972 US Open
Champion Ilie Năstase
Runner-up Arthur Ashe
Score3–6, 6–3, 6–7(1–5), 6–4, 6–3
Draw148
Seeds16

Ilie Năstase defeated Arthur Ashe in the final, 3–6, 6–3, 6–7(1–5), 6–4, 6–3 to win the men's singles tennis title at the 1972 US Open. It was his first major singles title, becoming the first Romanian to win a singles major.

Stan Smith was the defending champion, but lost in the quarterfinals to Ashe.

This marked the last major appearance of 12-time singles major champion Roy Emerson, who lost in the first round to Fred Stolle.