1880–81 FA Cup
| Tournament details | |
|---|---|
| Country | England |
| Teams | 62 |
| Defending champions | Clapham Rovers |
| Final positions | |
| Champions | Old Carthusians (1st title) |
| Runners-up | Old Etonians |
The 1880–81 Football Association Challenge Cup was the tenth staging of the FA Cup, England's oldest football tournament. Sixty-two teams entered, eight more than the previous season, although four of the sixty-two never played a match.