Final Fantasy I/Trivia

The webcomic 8-Bit Theater is very loosely based on this, and pays homage to the fact that much of the first game's mechanics were drawn from Dungeons and Dragons.
Breakthrough Hit: As mentioned on the main page, this game helped launch Square from being a small company who couldn't make a hit to being the JRPG juggernaut it eventually would be.
Fan Vid: The Adventures of Duane and BrandO's Final Fantasy medley is particularly noteworthy in this respect.
Word of Dante: A lot of people attribute the personalities of the Eight Bit Theater cast to the characters in the game. Of course, nobody has a personality in the game, so you can add pretty much whatever you want and it still works.